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Serio's Po-Boys & Deli is famously known for its signature muffaletta, a sandwich made with meat, cheese, and olive salad original to New Orleans. Serio's, which prides itself on a three-generations-old muffaletta recipe, was featured on Food Network's Throwdown with Bobby Flay. Locals rave that Serio's serves the best muffaletta in the city and that if you try it once, you'll keep coming back for more. Be sure to stop in for lunch during your tour of Downtown!